IMB-10, >=98% (HPLC)

Stock Code: 3573984
Manufacturer Part No: SML0022-5MG

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Descriptions

Application

IMB-10 may be used to study integrin-mediated signaling in tumor cells.

Biochem/physiol Actions

IMB-10 is a ligand for the αMβ2 integrin that stabilizes the binding of the integrin to endogenous ligands such as proMMP-9 and fibrinogen. IMB-10 blocks migration of lymphocyte cell lines and inhibits leukocyte infiltration in a murine thioglycolate-induced peritonitis.

IMB-10 is a thioxothiazolidine compound that inhibits the infiltration of leukocytes to the site of tumor and blocks the invasion of HSC-3 carcinoma. It modulates the host inflammatory responses and tumor progression.

Packaging

5, 25 mg in glass bottle

Specifications

Colour	yellow
Quality Level	100
InChI key	UYZLENPCNZVWQZ-QHMSGILQSA-N
InChI	1S/C19H15NOS2/c1-14-8-5-6-12-16(14)20-18(21)17(23-19(20)22)13-7-11-15-9-3-2-4-10-15/h2-13H,1H3/b11-7+,17-13+
Manufacturer	SIGMA-ALDRICH
Solubility	DMSO: ≥25 mg/mL
Form	powder
Assay	≥98% (HPLC)