Ubiquitin Carrier Protein H2 human,

Ubiquitin Carrier Protein H2 human,

Stock Code: 3593816
Manufacturer Part No: U2508-50UG
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Biochem/physiol Actions

UbcH2 is the human homolog to the yeast DNA repair gene RAD6 and is inducible by DNA damaging agents. Also associated with cancer-induced cachexia and the degradation of "N-end rule" substrates. UbcH2 mRNA level in muscle has also been correlated with sepsis. Moreover, c-Jun and c-Fos transcription factors have been shown to be ubiquitinated by an UbcH2-mediated event. TNF-? was shown to stimulate expression of UbcH2 in skeletal muscle cells by increasing binding of NF?-B to the promoter region of UbcH2, inducing transcription.

UbcH2 is the human homolog to the yeast DNA repair gene RAD6 and is inducible by DNA damaging agents. Also associated with cancer-induced cachexia and the degradation of "N-end rule" substrates. UbcH2 mRNA level in muscle has also been correlated with sepsis. Moreover, c-Jun and c-Fos transcription factors have been shown to be ubiquitinated by an UbcH2-mediated event.

Other Notes

manufactured for Sigma by Boston Biochem. Inc.

Physical form

Solution in 50 mM HEPES, 50 mM NaCl, 10% glycerol, 1mM DTT, pH 7.8

Quality Level200
ManufacturerSIGMA-ALDRICH
Formsolution
Assay>95% (SDS-PAGE)

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