Tumor Necrosis Factor Soluble Receptor I (TNF sRI) from mouse, , >97% (SDS-PAGE), recombinant, expre

Stock Code: 3593752
Manufacturer Part No: T3564-50UG

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Descriptions

Analysis Note

The biological activity is measured by its ability to inhibit the recombinant mouse TNF-? mediated cytotoxicity in mouse L929 cells, in the presence of the metabolic inhibitor actinomycin D.

Application

Tumor Necrosis Factor Soluble Receptor I (TNF sRI) from mouse plays a pivotal role in the signaling of apoptosis and NF-κB activation because of its “death domain” present at the intracellular portion.

Biochem/physiol Actions

Tumor Necrosis Factor Soluble Receptor I (TNF sRI) from mouse belongs to TNF family of receptors and has a pivotal role in neutralizing the biological activities of both TNF-? and TNF-?. Soluble tumor necrosis factor receptor along with intrathecal interleukin-1 receptor antagonist shows an anti-allodynic action in rat L5 spinal nerve transection model of neuropathic pain.

Physical form

Lyophilized from a 0.2 µm filtered solution in phosphate buffered saline with 2.5 mg bovine serum albumin