DLK, GST tagged human, recombinant, expressed in baculovirus infected Sf9 cells, >=70% (SDS-PAGE), b

DLK, GST tagged human, recombinant, expressed in baculovirus infected Sf9 cells, >=70% (SDS-PAGE), b

Stock Code: 3593580
Manufacturer Part No: SRP5365-20UG
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General description

DLK or mitogen-activated protein kinase kinase kinase 12 is a transmembrane protein containing six epidermal growth factor repeats and is a serine/threonine protein kinase. DLK is involved in the differentiation of several cell types, including adipocytes. DLK plays a role of a tumor suppressor protein and is predominately expressed in neuronal cells. DLK as an activator of the Jnk pathway. Overexpression of DLK results in activation of Jnk1 and the accumulation of a hyperphosphorylated form of c-Jun. Postnatal loss of DLK in stem cells and niche astrocytes has been shown to regulate neurogenesis.

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

Preparation Note

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

ManufacturerSIGMA-ALDRICH
Formbuffered aqueous glycerol solution
Assay≥70% (SDS-PAGE)

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