IKK-gamma, GST tagged human, recombinant, expressed in baculovirus infected Sf9 cells, >=70% (SDS-PA

IKK-gamma, GST tagged human, recombinant, expressed in baculovirus infected Sf9 cells, >=70% (SDS-PA

Stock Code: 3593565
Manufacturer Part No: SRP5349-20UG
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General description

IKKgamma is a serine/threonine protein kinase that phosphorylates the I-kappa-B protein which is an inhibitor of the transcription factor NF-kappa-B complex. Phosphorylation of I-kappa-B protein triggers the degradation of the inhibitor via the ubiquitination pathway, thereby activating NF-kappa-B complex. IKKgamma forms dimers and trimers and interacts preferentially with IKKbeta but not IKKalpha. IKKgamma associates with activated ATM after the induction of DNA double-strand breaks. ATM phosphorylates serine-85 of IKKgamma to promote its ubiquitin-dependent nuclear export.

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

Preparation Note

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

ManufacturerSIGMA-ALDRICH
Formbuffered aqueous glycerol solution
Assay≥70% (SDS-PAGE)

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