PP2C-alpha, active, GST tagged human, recombinant, expressed in baculovirus infected Sf9 cells, >=70

Stock Code: 3593554
Manufacturer Part No: SRP5335-10UG

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Descriptions

Biochem/physiol Actions

Protein phosphatase 2C-? (PP2C-?) or PPM1A is known to be negative regulators of cell stress response pathways. It has been reported to negatively regulate TGF-? signaling pathway and cell cycle. PP2C-? has been shown to dephosphorylate cyclin-dependent kinases (CDKs) and it may be involved in cell cycle control. It modulates cell migration and invasion. Overexpression of PP2C-? is reported to cause cell-growth arrest or cell death.

General description

Protein phosphatase 2C-? (PP2C-?), also called protein phosphatase, Mg²⁺/Mn²⁺ dependent 1A (PPM1A), is a member of the family of Ser/Thr protein phosphatases and is composed of a catalytic subunit and a constant regulatory subunit. PP2C-? is highly expressed in heart and skeletal muscle. The gene encoding this protein is localized on human chromosome 4q12.

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

Preparation Note

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.