SIRT6, active, His tagged human, recombinant, expressed in baculovirus infected Sf9 cells, >=70% (SD

SIRT6, active, His tagged human, recombinant, expressed in baculovirus infected Sf9 cells, >=70% (SD

Stock Code: 3593499
Manufacturer Part No: SRP5273-10UG
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General description

SIRT6 is a member of the sirtuin family of proteins which are homologs to the yeast Sir2 protein. Sirtuin family contain a sirtuin core domain and are grouped into four classes with SIRT6 being a member of class IV. Human SIRT6 protein is a NAD(+)-dependent histone H3 lysine-9 deacetylase that modulates telomeric chromatin. SIRT6 associates specifically with telomeres and SIRT6 depletion leads to telomere dysfunction with end-to-end chromosomal fusions and premature cellular senescence. SIRT6 -/- mouse cells show that SIRT6 promotes resistance to DNA damage and suppresses genomic instability in association with a role in base excision repair.

Physical form

Supplied in 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.2 mM DTT, 25% glycerol.

Preparation Note

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

ManufacturerSIGMA-ALDRICH
Formbuffered aqueous glycerol solution
Assay≥70% (SDS-PAGE)

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