EIF2S1, His tagged human, recombinant, expressed in E. coli, >=70% (SDS-PAGE), buffered aqueous glyc

EIF2S1, His tagged human, recombinant, expressed in E. coli, >=70% (SDS-PAGE), buffered aqueous glyc

Stock Code: 3593465
Manufacturer Part No: SRP5232-50UG
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Biochem/physiol Actions

Eukaryotic translation initiation factor 2 subunit 1 ? (EIF2S1) catalyzes the first regulated step of protein synthesis initiation and promotes the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. The Ser51 in the mature human EIF2-? protein acts as the sole site of phosphorylation that leads to repression of protein synthesis. EIF2-? also plays an essential role in erythropoiesis.

General description

Eukaryotic translation initiation factor 2 subunit 1 ? (EIF2S1) is a 35kDa protein. It is the ? subunit of the eukaryotic initiation factor 2 (eIF2?). The gene encoding it is localized on human chromosome 14q23.3.

Physical form

Supplied in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

ManufacturerSIGMA-ALDRICH
Formbuffered aqueous glycerol solution
Assay≥70% (SDS-PAGE)

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