c-JUN (1-79), GST tagged human, recombinant, expressed in E. coli, >=50% (SDS-PAGE), buffered aqueou

c-JUN (1-79), GST tagged human, recombinant, expressed in E. coli, >=50% (SDS-PAGE), buffered aqueou

Stock Code: 3593424
Manufacturer Part No: SRP5176-50UG
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General description

c-Jun is a proto-oncogene that forms a complex with c-Fos which regulates transcription from promoters containing AP-1 activation elements. c-Jun has specific DNA binding activity and following in vitro translation, c-Jun binds as a homodimer to the AP-1 DNA site. The transactivating function of c-Jun is acutely regulated by a wide variety of cellular signals via modulation of phosphorylation of two serines (63 and 73). Jun N-terminal domain kinases (JNKs), are responsible for mediating S63/73 phosphorylation on c-Jun in response to a variety of cellular stimuli including TNF-a, heat stress and u.v. light.

Physical form

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

ManufacturerSIGMA-ALDRICH
Formbuffered aqueous glycerol solution
Assay≥50% (SDS-PAGE)

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