Troponin1, His tagged human, recombinant, expressed in E. coli, >=70% (SDS-PAGE), buffered aqueous g

Troponin1, His tagged human, recombinant, expressed in E. coli, >=70% (SDS-PAGE), buffered aqueous g

Stock Code: 3593399
Manufacturer Part No: SRP5147-50UG
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General description

Troponin1 is a member of the tropomyosin family and regulates the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin1 is part of a complex with troponin T and troponin C in which Troponin1 acts as an inhibitory subunit that blocks actin-myosin interactions and thereby mediates striated muscle relaxation. Troponin1 is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The Troponin1 protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.

Physical form

Supplied in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

ManufacturerSIGMA-ALDRICH
Formbuffered aqueous glycerol solution
Assay≥70% (SDS-PAGE)

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