SLK, active, GST tagged human, PRECISIO Kinase, recombinant, expressed in baculovirus infected Sf9 c

SLK, active, GST tagged human, PRECISIO Kinase, recombinant, expressed in baculovirus infected Sf9 c

Stock Code: 3593350
Manufacturer Part No: SRP5086-10UG
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General description

SLK or LOSK is a Ste20-like protein kinase that associates with microtubule and centrosome. Inhibition of SLK activity by dominant-negative mutant or RNAi leads to unfocused microtubule arrangement indicating that SLK is needed for microtubule organization and for the proper localization of Golgi complex. Expression of v-Src can down-regulate SLK activity through the involvement of CK2 which can directly phosphorylate and inhibit SLK activity whereas inhibition of CK2 in v-Src-transformed cells results in normal SLK activity. CK2 and SLK can be co-localized in fibroblasts spreading on fibronectin-coated substrates.

Legal Information

PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC

Physical form

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

ManufacturerSIGMA-ALDRICH
Product LinePRECISIO® Kinase
Formbuffered aqueous glycerol solution
Assay≥70% (SDS-PAGE)

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