IL-1 RECEPTOR ANTAGONIST human,;, Animal-component free, recombinant, expressed in E. coli, >=98% (S

Stock Code: 3593272
Manufacturer Part No: SRP3327-100UG

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Descriptions

Application

Interleukin-1 receptor antagonist (IL-1RA) human has been used to block the IL-1? binding to its receptor. IL-1 receptor antagonist has been used to understand the role of autocrine interleukin-1? (IL-1?) signaling downstream of cl- in RPS27 modulation.

Biochem/physiol Actions

Interleukin-1 receptor antagonist (IL-1RA) inhibits the activity of IL-1? and IL-1? by competitively blocking binding to their type I and type II receptors. Therapeutically, IL-1RA may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease.

General description

Interleukin-1 receptor antagonist (IL-1RA) is a naturally occurring inflammatory inhibitor protein. IL-1Ra is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts. Recombinant human IL-1Ra is a 17.2kDa protein consisting of 153 amino acid residues.

Physical form

Lyophilized from 20 mM Tris, pH 8.0.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.