SDF-1 alpha from rat,;, recombinant, expressed in E. coli, >=98% (SDS-PAGE), >=98% (HPLC), cell cult

Stock Code: 3593208
Manufacturer Part No: SRP3252-10UG

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Descriptions

Application

Stromal cell-derived factor 1 ? (SDF-1? ) has been used in cell migration assay and fibrin gel bead assay.

Biochem/physiol Actions

Stromal cell-derived factor 1 ? and ? (SDF-1? and ?) chemoattract B and T cells, and have been shown to induce migration of CD34⁺ stem cells. Additionally, the SDF-1 proteins exert HIV suppressive activity in cells expressing the CXCR4 receptor. SDF-1 ? modulates leukocyte and hematopoietic precursor migration and pre-B cell proliferation.

General description

Stromal cell-derived factor 1 ? and ? (SDF-1? and ?) are stromal derived CXC chemokines, and signal through the C-X-C motif chemokine receptor-4 (CXCR4). SDF-1? is also known as C-X-C motif chemokine ligand 12 (CXCL12). Recombinant rat SDF-1? is a 7.9kDa protein containing 68 amino acid residues.

Physical form

Lyophilized with no additives.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Sequence

KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKSNNRQVC IDPKLKWIQE YLDKALNK