p53 (1-363) C-terminal deletion human, recombinant, expressed in insect cells, >=80% (SDS-PAGE)

Stock Code: 3592910
Manufacturer Part No: SRP2077-5UG
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Biochem/physiol Actions

Human p53 protein is composed of 393 amino acid residues with several distinct regions. The N-terminal activation domain allows p53 protein to recruit the basal transcription machinery and activate the expression of target genes, whereas the core domain binds to target DNA in a sequence-specific manner and the majority of mutations found in human tumors occur in the region of the gene encoding this domain. The C-terminal domain is composed of predominantly basic residues and modification of the C-terminal basic domain, including acetylation, glycosylation and phosphorylation, is an essential mechanism for regulating p53 function.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Colourclear colorless
ManufacturerSIGMA-ALDRICH
Formfrozen liquid
Assay≥80% (SDS-PAGE)

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