Topo I (N1-197) (NTD) human, recombinant, expressed in insect cells, >=85% (SDS-PAGE)

Topo I (N1-197) (NTD) human, recombinant, expressed in insect cells, >=85% (SDS-PAGE)

Stock Code: 3592879
Manufacturer Part No: SRP2034-5UG
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Biochem/physiol Actions

Human DNA topoisomerase I is the best studied of the DNA topoisomerase family. It catalyzes the relaxation of both positive and negative supercoils without the requirement of energy. In addition to DNA replication and transcriptional activation, DNA topoisomerase I also plays a major role in pre-mRNA splicing, cell cycle and other gene regulatory pathways during cell growth and development. The N-terminal 214 amino acids of topoisomerase I comprise a highly charged N-terminal domain (NTD) involved in protein-protein interactions with a number of cellular proteins, including SV40 T antigen, nucleolin, SR proteins, p53 and other transcription factors.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Colourclear colorless
ManufacturerSIGMA-ALDRICH
Formfrozen liquid
Assay≥85% (SDS-PAGE)

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