Ataxin3 active human, recombinant, expressed in E. coli, >=59% (SDS-PAGE)

Ataxin3 active human, recombinant, expressed in E. coli, >=59% (SDS-PAGE)

Stock Code: 3592810
Manufacturer Part No: SRP0445-250UG
Order Now for 7 day delivery
Click Add to Quote for price and delivery
Quantity: - +

Application

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Biochem/physiol Actions

Ataxin3 (ATXN3) is a polyglutamine neurodegenerative disease protein involved in the ubiquitin-proteasome pathway. ATXN3 performs all the functions same as ubiquitin proteases such as, reducing polyubiquitylation of 125I-lysozyme by removing ubiquitin from polyubiquitin chains, cleaving a ubiquitin protease substrate and binding the specific ubiquitin protease inhibitor, ubiquitin-aldehyde. Mutation in the gene has been observed in spinocerebellar ataxia type 3 patients.

General description

Ataxin3 (ATXN3) is encoded by the gene mapped to human chromosome 14q32. The encoded protein is characterized with a ubiquitin interaction motif (UIM) domain involved in binding mono and/or polyubiquitylated proteins.

ManufacturerSIGMA-ALDRICH
Formaqueous solution
Assay≥59% (SDS-PAGE)

There are no downloads for this product.