Sestrin 2 human, recombinant, expressed in baculovirus infected Sf9 cells, >=35% (SDS-PAGE)

Stock Code: 3592781
Manufacturer Part No: SRP0412-50UG

Order Now for 7 day delivery

Click Add to Quote for price and delivery

Quantity: - +

Descriptions

Application

Sestrin 2 human may be used to study its role on blood brain- barrier (BBB) stabilization after moderate and severe hypoxic- ischemic (HI) injuries in neonatal rats.

Biochem/physiol Actions

Sestrin 2 (SESN2) plays a vital role in modulating cellular stress response and oxidant defense. It plays a regulatory role in energy metabolism, cell fate, liver diseases, inflammation, and carcinogenesis. This novel anti-aging protein aids to maintain mitochondrial activities and enhance mitochondrial health. Since SESN2 is capable of protecting tissues from oxidative stress and mitochondrial dysfunction caused by ischemia or reperfusion (I/R), it may be a promising therapeutic target in hepatic regeneration.

General description

Sestrin 2 (SESN2), a highly conserved protein, is a member of a family of anti-aging proteins called the sestrins. Human SESN2 (hSESN2) contains three subdomains, such as SESN-A, SESN-B, and SESN-C. The SESN2 gene is mapped to human chromosome 1p35.3.