Histone H3 peptide (Di-methylated K9), biotin, >=95% (HPLC)

Stock Code: 3592769
Manufacturer Part No: SRP0398-500UL

Order Now for 7 day delivery

Click Add to Quote for price and delivery

Quantity: - +

Descriptions

Application

Study enzyme kinetics, and screen small molecular inhibitors of JMJ for drug discovery and HTS applications.

Biochem/physiol Actions

Histone proteins are basic building blocks of chromatin. Post-translational modifications of histone tails controls chromatin organization and gene transcription. Histone H3 lysine 9 dimethylation (H3K9me2) serves as an epigenetic marker for gene repression and silencing. This modification plays a significant role in embryogenesis and carcinogenesis. Histone methyltransferase G9a is responsible for hypoxic stress-mediated H3K9me2 in mammalian cells

General description

The mammalian chromatin is present in nucleosomes, made of histone octamers (H2A,H2B,H3,H4)₂. Mammals contain three main classes of histone H3 variants: the replicative histones (H3.1 and H3.2), the replacement histone (H3.3) and the centromeric histone (Cenp-A). Dimethylated histone H3 lysine 9 (H3K9me2) is mainly present in euchromatin and is linked with repressed promoter areas.

Other Notes

500 µL at 40 µM, or 20 nmol Sold as 500 µL