ATAT1 human, recombinant, expressed in E. coli, >=55% (SDS-PAGE)

Stock Code: 3592697
Manufacturer Part No: SRP0309-50UG

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Descriptions

Biochem/physiol Actions

ATAT1 (? tubulin acetyltransferase 1) catalyses the acetylation of lysine 40 of ?-tubulin and microtubule. ATAT1 expression is essential for microtubule stabilization and mediates cilium formation. Upart from acetylation, ?TAT1 interacts with doublecortin (a microtubule associated protein) to degrade microtubules that are not aligned with acetyltransferase activity. ?TAT1 regulates the Wnt1 signalling pathway via ?-catenin and promotes tumorigenesis. Overexpression of the ATAT1 gene is observed in colon cancer and is known to contribute to its progression.

General description

Human ? tubulin acetyltransferase 1, or ATAT1, (GenBank Accession No. NM_001031722 (var1)), amino acids 2 – 224 with N-terminal GST-tag, MW=52kDa, expressed in an E. coli expression system.The ?TAT1 (? tubulin acetyltransferase 1) protein sequence of ?TAT1 is highly conserved among eukaryotes. ?TAT1 is a member of Gcn5 (general control non-depressible 5)-related N-acetyltransferase superfamily and is mostly present in ciliated organisms. It has also been identified in Tetrahymena, nematodes, zebrafish and mice.