TGF-beta1 Latent human, recombinant, expressed in FreeStyle 293-F cells, >=98% (SDS-PAGE)

TGF-beta1 Latent human, recombinant, expressed in FreeStyle 293-F cells, >=98% (SDS-PAGE)

Stock Code: 3592690
Manufacturer Part No: SRP0300-5UG
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Application

Useful for cell culture and for the study of signaling and apoptotic pathways.

Biochem/physiol Actions

LTBP1 (latent transforming growth factor ? binding protein 1) is an extracellular matrix protein which also controls TGF-? (transforming growth factor ?) bioavailability. LTBP1 is mainly responsible for the folding and secretion of TGF-?, thereby adding it to the extracellular matrix. It is a target of HTRA1 (high temperature requirement protein A1), a serine protease involved in cellular signaling.

General description

Human TGF?1 (GenBank Accession No. NM_000660), amino acids 30-390 (end) with Cys33Ser mutation and N-terminal His-tag, disulfide-linked homodimers of TGF?1 LAP and mature TGF?1, MW= ~75kDa and 25kDa, under non-reducing conditions.LTBP1 (latent transforming growth factor ? binding protein 1) belongs to the LTBP family of proteins. The protein has 18 epidermal growth factor (EGF)-like repeats and four LTBP-like repeats. The gene is mapped to human chromosome 2p22.3.

Legal Information

FreeStyle is a trademark of Invitrogen Corp.

Physical form

Lyophilized from a 0.2 µM filtered, aqueous solution.

Reconstitution

Reconstitute in sterile PBS with 0.1% BSA. Stability: >6 months at –70°C (as a solid). Store reconstituted protein in aliquots at –80°C for up to 3 months. Avoid freeze/thaw cycles.

ManufacturerSIGMA-ALDRICH
Formaqueous solution
Assay≥98% (SDS-PAGE)

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