Furin Inhibitor II, >=98% (HPLC)

Stock Code: 3592419
Manufacturer Part No: SCP0148-5MG

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Descriptions

Amino Acid Sequence

Mpa-Mpa-Mpa-Mpa-Mpa-Mpa

Application

Furin Inhibitor II has been used as a furin inhibitor: to study its effects on transforming growth factor ?1 (TGF-?1) induced glial cell line-derived neurotrophic factor (GDNF) production in non-tumorigenic immortalized human granulosa cell line (SVOG). to study its effect on cleavage of (Pro) renin receptor (PRR) induced by bovine serum albumin (BSA) in human kidney 2 (HK-2) cells.in furin cleavage assay.

Biochem/physiol Actions

Furin plays a role in processing several pro-proteins such as, bone morphogenetic protein4 (BMP-4), insulin receptor and Notch1 receptor. It also processes human immune deficiency virus 1 (HIV-1) glycoprotein gp160, several metalloproteasesand pro-?-nerve growth (pro-?-NGF) factor. Furin is also involved in cleaving transforming growth factor ?1 (TGF-?1).

General description

Furin is a calcium-dependent serine endoproteinase and belongs to the subtilisin-like proprotein/prohormone convertase (PC) family. It is distributed ubiquitously and has a rhythmic movement between the trans-Golgi network, cell surface and the endosomes.