gamma Secretase Inhibitor, >=95% (HPLC)

gamma Secretase Inhibitor, >=95% (HPLC)

Stock Code: 3592253
Manufacturer Part No: SCP0004-5MG
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Amino Acid Sequence

Z-Leu-Leu-Nle-al

Application

? Secretase Inhibitor has been used to study the suppressive miR-129 functions through inhibition on estrogen receptor 1 (ESR1) and NOTCH signaling in breast cancer stem cells.

General description

Gamma-secretase is a protein complex containing presenilin, nicastrin, APH-1, and PEN-2. The leupeptin analogue Z-Leu-Leu-Nle-al (N-benzyloxycarbonyl-Leu-Leu-norleucinal; Benzyloxicarbonyl-Leu-Leu-Nle-CHO (LLNle)) and closely related peptides are used as protease and a gamma secretase inhibitors.

ManufacturerSIGMA-ALDRICH
CompositionPeptide Content, ≥85%
Storage Temp.−20°C
Formlyophilized
Assay≥95% (HPLC)

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