[D-Arg1, D-Phe5, D-Trp7,9, Leu11]-Substance P, >=95% (HPLC)

[D-Arg1, D-Phe5, D-Trp7,9, Leu11]-Substance P, >=95% (HPLC)

Stock Code: 3592184
Manufacturer Part No: S3144-1MG
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Amino Acid Sequence

Arg-Pro-Lys-Pro-Phe-Gln-Trp-Phe-Trp-Leu-Leu-NH2

Biochem/physiol Actions

Somatostatin plays an important role in regulating the metabolism of other hormones such as growth hormone, insulin, IGF-1 (insulin-like growth factor 1), glucagon, glucagon-like peptide and gastrin. Somatostatin has both regulatory and inhibitory functions. It retards gastrointestinal motility and gallbladder contraction, suppresses gut exocrine secretion and reduces epithelial proliferation. Somatostatin is associated with intestinal nutrient absorption and blood flow regulation. This peptide hormone is believed to inhibit cell proliferation and promote apoptosis. Somatostatin acts as a neurotransmitter and neuromodulator, and is also associated in maintaining water balance.

NK-1 tachykinin receptor antagonist

General description

The somatostatin gene codes for a peptide hormone containing 14 and 28 amino acid moieties. SST-14 is highly expressed in the central nervous system and peripheral organs. SST-28 is mainly expressed in enteroendocrine cells of the intestine.

Packaging

1 mg in glass bottle

Quality Level200
InChI keyXVOCEQLNJQGCQG-ACRSGXKRSA-N
InChI1S/C79H109N19O12/c1-46(2)38-59(68(83)100)91-70(102)60(39-47(3)4)92-73(105)64(43-51-45-88-56-28-14-12-25-53(51)56)95-72(104)61(40-48-20-7-5-8-21-48)93-74(106)63
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
Assay≥95% (HPLC)

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