PTP-beta human, >=95%, recombinant, expressed in E. coli K12, GST-tagged, buffered aqueous glycerol

PTP-beta human, >=95%, recombinant, expressed in E. coli K12, GST-tagged, buffered aqueous glycerol

Stock Code: 3592043
Manufacturer Part No: P9864-10000UN
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Biochem/physiol Actions

Dephosphorylates tyrosine proteins.

General description

Protein tyrosine phosphatase, receptor type B (PTPRB), also known as vascular endothelial-protein-tyrosine phosphatase (VE-PTP), might have a role in remodeling of blood vessels and in angiogenesis. The gene encoding it is localized on human chromosome 12q15. It is also important for endothelial cell migration. The protein also controls the phosphorylation state of the angiopoietin receptor, Tie-2. PTPRB may modulate sodium channels by influencing the tyrosine phosphorylation status.

Physical form

solution in 40?mM Tris-HCl, pH 8.0, 110?mM NaCl, 2.2 mM KCL, 3?mM DTT, 16 mM glutathione and 20% glycerol

Unit Definition

One unit of PTP-β will hydrolyze 1.0?nanomole of p-nitrophenyl phosphate per min at 30?°C.

Quality Level200
ManufacturerSIGMA-ALDRICH
Formbuffered aqueous glycerol solution
Assay≥90%

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