Protein Kinase A inhibitor fragment 14-22, myristoylated trifluoroacetate salt, >=90% (HPLC), lyophi

Stock Code: 3592038
Manufacturer Part No: P9115-1MG
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Amino Acid Sequence

Myr-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2

Application

Protein kinase A inhibitor fragment 14-22, myristoylated trifluoroacetate salt has been used in cell culture for pharmaceutical inhibition and activation studies.

Biochem/physiol Actions

Mutations in the gene encoding protein kinase cAMP-activated catalytic subunit-? (PRKACA) have been associated with Cushing’;s syndrome.

Cell permeable cAMP-dependent protein kinase (PKA) inhibitor

General description

Protein kinase A inhibitor fragment 14-22, myristoylated trifluoroacetate salt inhibits the protein kinase cAMP-activated catalytic subunit-? (PRKACA). The gene encoding it is localized on human chromosome 19p13.1.

Quality Level100
InChI keyDBHNUJXUTKVLID-UXBYPZMDSA-N
InChI1S/C53H100N20O12.C2HF3O2/c1-6-8-9-10-11-12-13-14-15-16-17-24-39(76)65-29-40(77)69-35(22-19-26-63-52(58)59)48(83)73-43(33(5)74)50(85)66-30-41(78)68-34(21-18-25-
ManufacturerSIGMA-ALDRICH
SolubilityH2O: soluble
Formlyophilized powder
Assay≥90% (HPLC)

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