CTOP, >=97% (HPLC)

CTOP, >=97% (HPLC)

Stock Code: 3592008
Manufacturer Part No: P5296-1MG
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Amino Acid Sequence

Phe-Cys-Tyr-Trp-Orn-Thr-Pen-Thr-NH2 [Disulfide Bridge: 2-7]

Application

CTOP has been used:to study the anxiogenic effects induced by CTOP in mice and rat.to study the effect of ?-opioid antagonist, CTOP on the bovine milk-derived LF (BLF)-induced analgesia.to determine whether ?-opioid receptors act cooperatively with 5-hydroxytryptamine (5-HT1A) receptors to regulate the behaviors generated in the elevated T-maze (ETM).

Biochem/physiol Actions

D-Pen-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) inhibits acute morphine-induced hypermotility and analgesic effect of morphine in a dose-dependent manner in vivo.

Selective ligand for µ-opioid receptors.

General description

D-Pen-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) is a selective cyclic ?-opioid receptor antagonist.

Linkage

Somatostatin analog

Quality Level100
InChI keyPZWWYAHWHHNCHO-FGHAYEPSSA-N
InChI1S/C50H67N11O11S2/c1-26(62)39(42(53)65)59-49(72)41-50(3,4)74-73-25-38(58-43(66)33(52)21-28-11-6-5-7-12-28)47(70)56-36(22-29-16-18-31(64)19-17-29)45(68)57-37(23
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
Formpowder
Assay≥97% (HPLC)

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