NEK6, active, GST tagged human, PRECISIO Kinase, recombinant, expressed in baculovirus infected Sf9

Stock Code: 3591886
Manufacturer Part No: N9788-10UG

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Descriptions

Biochem/physiol Actions

NEK6 is a serine/threonine kinase that is a member of the Nek family of protein kinases that share an amino-terminal catalytic domain related to NIMA family. NEK6 is a nuclear and cytoplasmic kinase that is required for mitotic progression of human cells. NEK6 is phosphorylated and activated during M phase of the cell cycle.Inhibition of NEK6 function by either overexpression of an inactive NEK6 mutant or elimination of endogenous NEK6 by siRNA arrests cells in M phase and triggers apoptosis.

Legal Information

PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.