Microsomes from Liver, Pooled, ~10 mg per vial, from rat (Sprague-Dawley), female

Stock Code: 3591830
Manufacturer Part No: M9191-1VL

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Descriptions

Biochem/physiol Actions

Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.

Unit Definition

One unit will reduce 1 nanomole of cytochrome C per minute at pH 7.4 at 37 deg C.7-ethoxyresorufin O-deethylase activity: One unit will hydroxylate 1.0 picomole paclitaxel per minute at pH 7.4 at 37 deg C.