MET (956-end), active, GST tagged human, PRECISIO Kinase, recombinant, expressed in baculovirus infe

Stock Code: 3591705
Manufacturer Part No: M0574-10UG

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Descriptions

Biochem/physiol Actions

MET is a proto-oncogene that encodes a transmembrane growth factor receptor which is a heterodimer of two disulfide linked chains of 50 kDa (alpha) and 145 kDa (beta). MET is widely expressed in the kidney, brain, lung, skin, and embryonic tissue. Hepatocyte growth factor (HGF) binds to MET and activates its tyrosine kinase activity. MET is overexpressed and activated in a variety of human cancers including pancreatic, colon, gastric, cervical and ovariancancers and has been shown to be involved in tumor cell migration and invasion.

Legal Information

PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.