PKCtheta, active, GST tagged human, PRECISIO Kinase, recombinant, expressed in baculovirus infected

Stock Code: 3591603
Manufacturer Part No: K4643-10UG

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Descriptions

Biochem/physiol Actions

PKC? (protein kinase C ?) is required for T cell activation and proliferation. In presence of TCR (T cell receptor) stimulation, it is responsible for activation of NF-AT (nuclear factor of activated T-cells), NF-?B (nuclear factor ? B) and AP1 (adaptor-related protein complex 1). It might be a target for the treatment of type 2 diabetes. PKC? is needed for fat-mediated insulin resistance in skeletal muscle.

General description

PKC? (protein kinase C ?) is a serine/threonine kinase, belonging to protein kinase C family.

Legal Information

PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.