PKC? (protein kinase C ?) is involved in cell proliferation, differentiation as well as migration. Mutations in PKC? are associated with neurodegenerative disease, spinocerebellar ataxia type 14. Single nucleotide polymorphisms in PKC? are also linked with high risk of osteosarcoma.
General description
PKC? (protein kinase C ?) is a s a serine/threonine kinase belonging to the protein kinase C (PKC) family. PKC? is mainly present in the central nervous system and is strongly expressed in cerebellar Purkinje cells.
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Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.