PKCzeta, active, GST tagged human, PRECISIO Kinase, recombinant, expressed in baculovirus infected S

Stock Code: 3591598
Manufacturer Part No: K4018-10UG

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Descriptions

Biochem/physiol Actions

PKC? (protein kinase C ?) is a atypical PKC and works independent of Ca²⁺ and diacylglycerol. It is involved in MAPK (mitogen-activated protein kinase)-induced nuclear factor ? B activation. It also stabilizes DNA mismatch-repair proteins, participates in laeukemic cell differentiation, cell migration and chemotaxis. PKC? have tumour suppressor as well as oncogenic properties. Upregulation of PKC? causes apoptosis in ovarian carcinoma cells. On the other hand, absence of PKC? decreases tumorigenic activity in a colon cancer mouse model.

Legal Information

PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.