Interleukin-17A human, >=98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, cell

Interleukin-17A human, >=98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, cell

Stock Code: 3591530
Manufacturer Part No: I3525-50UG
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Analysis Note

The biological activity of human IL-17 is measured by its ability to induce IL-6 production using NHDF cells. Biological activity is also determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblast. The expected ED50 is ﹤ 2.0 ng/ml, corresponding to a specific activity of > 5 x 105 units/mg.

Biochem/physiol Actions

IL-17, initially known as CTLA-8, is a T cell-expressed polypeptide that appears to be involved in the regulation of the hematopoietic system. IL-17 has been shown to induce IL-6, IL-8, and G-CSF production by fibroblasts; all of these cytokines have demonstrated effects on hematopoiesis.

Physical form

Lyophilized with no additives.

ManufacturerSIGMA-ALDRICH
Impuritiesendotoxin, tested (endotoxin level is less than 0.1 ng per µg cytokine (1 EU/µg).)
Formlyophilized powder
Assay≥98% (SDS-PAGE)

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