[Tyr(SO3H)63]-Hirudin Fragment 54-65, >=95% (HPLC)

Stock Code: 3591462
Manufacturer Part No: H6894-.1MG

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Descriptions

Amino Acid Sequence

Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr(SO3H)-Leu-Gln

Application

[Tyr(SO₃H)⁶³]-hirudin fragment 54-65 has been used to study the effect of thrombin in presence of leupeptin. It is also used to study the effect of hirudin peptide on the thrombin-rHCII (recombinant heparin cofactor II)-L444R (leucine 444 to arginine) complex separation.

Biochem/physiol Actions

Hirudin fragment that binds to the regulatory exosite I on thrombin and the regulatory proexosite I on prothrombin. The interaction with thrombin prevents the thrombin-induced activation of clotting factor V. The interaction with prothrombin inhibits the formation of thrombin by factor Xa in the presence of factor Va.

Specifications

Quality Level	200
InChI key	CKXMQSIWBKKXGT-UHFFFAOYSA-N
InChI	1S/C66H93N13O28S/c1-5-34(4)55(78-59(95)41(21-26-53(88)89)71-56(92)38(18-23-50(82)83)72-61(97)44(29-35-10-7-6-8-11-35)77-63(99)46(31-54(90)91)69-49(81)32-67)65(
Manufacturer	SIGMA-ALDRICH
Storage Temp.	−20°C
Form	powder
Assay	≥95% (HPLC)