Glucagon-Like Peptide 1 Fragment 7-37 human, >=96% (HPLC)

Glucagon-Like Peptide 1 Fragment 7-37 human, >=96% (HPLC)

Stock Code: 3591383
Manufacturer Part No: G9416-.5MG
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Amino Acid Sequence

His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala- Trp-Leu-Val-Lys-Gly-Arg-Gly

Application

Glucagon-Like Peptide 1 Fragment 7-37 human has been used:as a positive control for insulin secretion of pancreatic isletsto test its effect on insulin response in horse isletsin combination with mesenchymal stem cells (MSCs) test its protective effects in myocardial infarction

Biochem/physiol Actions

Glucagon-Like Peptide 1 Fragment 7-37 human (GLP-1-(7-37)) interacts with the GLP-1 receptor (GLP-1r). It mediates insulin release by stimulating the cyclic AMP accumulation in islet cells GLP-l(7-37) is a potential therapeutic agent due to its insulin-secretagogue functionality.

General description

Glucagon-Like Peptide 1 Fragment 7-37 human (GLP-1-(7-37)) is an amino-truncated form of GLP-1.

GLP-1 (7-37) is a truncated, bioactive form of GLP-1 that is the product of proglucagon processing in intestinal endocrine L cells. It is a potent insulinotropic hormone.

Other Notes

Lyophilized from 0.1% TFA in H2O

Packaging

0.5 mg in glass bottle

Quality Level200
InChI keyGCYXWQUSHADNBF-AAEALURTSA-N
InChI1S/C151H228N40O47/c1-17-77(10)121(148(236)169-81(14)127(215)177-105(60-87-63-160-92-36-25-24-35-90(87)92)138(226)179-101(56-74(4)5)139(227)188-119(75(6)7)146(2
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
Assay≥96% (HPLC)

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