Gc-globulin from human plasma, >=90% (SDS-PAGE), lyophilized powder (containing sodium chloride and

Gc-globulin from human plasma, >=90% (SDS-PAGE), lyophilized powder (containing sodium chloride and

Stock Code: 3591368
Manufacturer Part No: G8764-1MG
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Application

Gc-globulin from human plasma has been used:as a fluorescent probe for G-actin stainingas a fluorescent probe to monitor steady-state rate of actin filament disassemblyas a calibrator for liquid chromatography with mass spectrometry (LC-MS/MS)

Gc-globulin is a multifunctional, albumin-like plasma protein that often requires cell surface binding to mediate some of its diverse functions. It has been used to anlayze its glycosylation patterns.

Biochem/physiol Actions

Single nucleotide polymorphism in the gene GC is associated with deficiency of 25-hydroxyvitamin D [25(OH)D].

Gc-Globulin, a member of the albumin superfamily, is the major plasma carrier of vitamin D and its metabolites. It is also, along with gelsolin, a part of the extracellular actin scavenger system. Gc-globulin also binds monomeric actin (G-actin) with high affinity to scavenge actin released by necrotic cells, preventing its polymerization into filaments. Gc-globulin enhances the chemoattractant activity of C5a for inflammatory cells.

General description

Gc-Globulin, a member of the albumin superfamily, is the major plasma carrier of vitamin D and its metabolites. It is also, along with gelsolin, part of the extracellular actin scavenger system. Gc-globulin also binds monomeric actin (G-actin) with high affinity to scavenge actin released by necrotic cells, preventing its polymerization into filaments. Gc-globulin enhances the chemoattractant activity of C5a for inflammatory cells.

Gc-globulin from human plasma is encoded by the gene GC, which is mapped to human chromosome 4q13.3.

Gc-globulin or the vitamin D binding protein (DBP) is a 51-58 kDa multifunctional serum glycoprotein synthesized in large quantities by primarily in the liver. It is a member of the albumin gene family and has the characteristic multiple disulfide-bonded, triple domain structure.

Preparation Note

Native Gc-globulin from human plasma

Quality Level200
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
SolubilityH2O: soluble 2 mg/mL
Formlyophilized powder (containing sodium chloride and sodium phosphate buffer salt)
Assay≥90% (SDS-PAGE)

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