GRK5, active, GST tagged human, PRECISIO Kinase, recombinant, expressed in baculovirus infected Sf9

Stock Code: 3591365
Manufacturer Part No: G8296-10UG

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Descriptions

Biochem/physiol Actions

GRK5 (G protein-coupled receptor kinase 5) controls the functions of catecholamines, which bind and activate ?-adrenergic receptors, and have cardiac inotropic and chronotropic actions. It is responsible for the uncoupling from G protein by facilitating ?1-adrenergic receptor phosphorylation and ?-arrestin recruitment. This protein plays a key role in growth and metastasis in prostate cancer, where it phosphorylates moesin.† A genome-wide association study (GWAS) has shown that rs10886471 variant in GRK5 gene is linked with susceptibility to type 2 diabetes mellitus (T2DM).

General description

GRK5 (G protein-coupled receptor kinase 5) belongs to the G-protein coupled receptor kinase family, and shows major expression in normal human heart. This protein contains a nuclear localization sequence and hence localizes in nucleus.

Legal Information

PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.