GDF-15 human,

Stock Code: 3591305
Manufacturer Part No: G3046-25UG
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Analysis Note

Under reducing conditions in SDS-PAGE, each recombinant GDF-15 monomer migrates as an ~14 kDa protein.

Application

Growth-differentiation factor-15 (GDF-15) has been associated in the regulation of cell survival, proliferation, and differentiation and also in the protection from ischemia/reperfusion injury. Inflammatory and apoptotic pathways are regulated in injured tissues by GDFs during disease processes.

Biochem/physiol Actions

Although it has been classified as a divergent member of the transforming growth factor-? superfamily, GDF-15 shares structural characteristics with this superfamily. It has been identified as a biomarker for human prostate cancer. Additionally, increased GDF-15 expression has been observed in breast, pancreas and colorectal cancers. Functions of this cytokine include inhibition of TNF-? production, initiation of cartilage formation, and promotion of neuronal survival.It has been discussed to serve as a secreted biomarker for activation of the p53 pathway in human cancer.

General description

Growth-differentiation factor-15 (GDF-15) is a stress-responsive member of the transforming growth factor-? cytokine superfamily. It is also known as PTGF-Growth-differentiation factor-15 (GDF-15) and is a stress-responsive member of the transforming growth factor-? cytokine superfamily.2 It is also known as PTGF-?, TGF-PL or MIC-1?, TGF-PL or MIC-1.

Physical form

Lyophilized from a 0.2 µm filtered solution in 30% acetonitrile, 0.1% trifluoroacetic acid containing 50 µg of bovine serum albumin per 1 µg of GDF-15.

Quality Level100
ManufacturerSIGMA-ALDRICH
Impuritiesendotoxin, tested
Formlyophilized powder
Assay>97% (visualized with silver stain, SDS-PAGE)

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