Gly-Arg-Gly-Asp-Ser-Pro-Lys, >=97% (HPLC)

Stock Code: 3591262
Manufacturer Part No: G1269-1MG

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Descriptions

Amino Acid Sequence

Gly-Arg-Gly-Asp-Ser-Pro-Lys

Application

Gly-Arg-Gly-Asp-Ser-Pro-Lys (RGD peptide) has been used-as a blocking peptide to inhibit integrin-fibronectin bindingin adhesion assay performed on porcine trophectoderm to study the influence of TGF? (transforming growth factor) on cell adhesionfor incubation of MC3T3-E1 osteoblast cells to determine its effect on cell adhesion measured by AFM (atomic force microscopy)for the preparation of RGD.Flt23k.NR nanoparticlesto determine the involvement of RGD-integrin bonding in cell adhesion process

Biochem/physiol Actions

Fibronectin analog that binds to integrins.

General description

Gly-Arg-Gly-Asp-Ser-Pro-Lys is a RGD peptide. Naturally occurring RGD peptides, present in the ECM (extracellalar matrix) proteins, are involved in facilitating integrin-mediated cell adhesion to matrix proteins. RGD peptide is present as repeats in cell-adhesion protein, such as fibronectin and vitronectin. This tripeptide is recognized by cells by specific integrins (e.g. ?1 , ?3 , and ?5 subunits), present on the cell surface and associated with the actin filament via the FA (focal adhesion)-complex.

Specifications

Quality Level	200
InChI key	ZRVZOBGMZWVJOS-VMXHOPILSA-N
InChI	1S/C28H49N11O11/c29-8-2-1-5-16(27(49)50)37-25(47)19-7-4-10-39(19)26(48)18(14-40)38-24(46)17(11-22(43)44)36-21(42)13-34-23(45)15(35-20(41)12-30)6-3-9-33-28(31)3
Manufacturer	SIGMA-ALDRICH
Form	powder
Assay	≥97% (HPLC)