DAPK1 (1-363), active, GST tagged human, PRECISIO Kinase, recombinant, expressed in baculovirus infe

Stock Code: 3591072
Manufacturer Part No: D7069-10UG

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Descriptions

Biochem/physiol Actions

Death-associated protein kinase 1 (DAPK1) is a positive mediator of apoptosis induced by g-interferon. Activation of DAPK occurs via dephosphorylation of Ser-308 and subsequent association of calcium/calmodulin. DAPK is rapidly dephosphorylated in response to tumor necrosis factor or ceramide and then subsequently degraded via proteasome activity. The decline in DAPK expression is paralleled with increased caspase activity and cell apoptosis. Studies suggest that the apoptosis regulatory activities mediated by DAPK are controlled both by phosphorylation status and protein stability.

Legal Information

PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.