Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl]), >=95% (HPLC), powder

Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl]), >=95% (HPLC), powder

Stock Code: 3589906
Manufacturer Part No: C4801-1MG
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Amino Acid Sequence

cyclo-Phe-Trp-Lys-Thr-Bzl

Application

Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl]) has been used as a somatostatin antagonist to study its effects on sleep in rats to infer the role of endogenous somatostatin in the physiologic modulation of REM sleep (REMS) , as an somatostatin (SST) antagonist to study its effects on elemental-induced intestinal atrophy in rats , as an SST receptor antagonist to eliminate the effect of somatostatin on catecholamine .

Biochem/physiol Actions

Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl]) (cSSTA) is a cyclic somatostatin (SST) analog and is a somatostatin receptor antagonist. It is involved in blocking the effect of somatostatin, such as airway ?-adrenergic function and regulation of acetylcholine release. cSSTA is also involved in blocking the effect of somatostatin of hormone release andcorticotropin-releasing factor-induced suppression of gastric emptying.

Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl]), also known as cyclosomatostatin. Inhibition of somatostatin receptors by cyclosomatostatin induces catalepsy in rats.

Colourwhite
Quality Level200
InChI keyYHVHQZYJGWGAKN-ZUWUZHNASA-N
InChI1S/C44H57N7O6/c1-30(57-29-32-18-8-5-9-19-32)40-44(56)46-25-15-3-2-10-23-39(52)48-37(26-31-16-6-4-7-17-31)42(54)50-38(27-33-28-47-35-21-12-11-20-34(33)35)43(55)
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥95% (HPLC)

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