Cytochrome c from pigeon breast muscle, based on Mol. Wt. 12,173 basis, >=95% based on Mol. Wt. 12,1

Cytochrome c from pigeon breast muscle, based on Mol. Wt. 12,173 basis, >=95% based on Mol. Wt. 12,1

Stock Code: 3589882
Manufacturer Part No: C4011-25MG
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Application

Cytochrome c has been identified as an important mediator in apoptotic pathways. The release of mitochondrial cytochrome c into the cytoplasm stimulates apoptosis and is commonly used as an indicator of the apoptotic process in the cell. Investigation on the effect of Paris Saponin I (PS I) on human gastric carcinoma cell growth (SGC7901 cells) have shown an elevated level cytoplasmic cytochrome c. Results are an inhibition of proliferation in SGC7901 cells by inducing mitochondria-dependent apoptosis through cytochrome c.

Biochem/physiol Actions

The ready fluctuation of cytochrome c within the cell between ferrous and ferric states, makes it an efficient biological electron-transporter. It plays a vital role in cellular oxidations in both plants and animals. Generally regarded as a universal catalyst of respiration, it forms the essential electron-bridge between the respirable substrates and oxygen.

Other Notes

View more information on cytochrome c and electron transport at www.sigma-aldrich.com/enzymeexplorer.

Packaging

25, 250 mg in glass bottle

Preparation Note

Prepared with acetic acid without using TCA.

Quality Level200
ManufacturerSIGMA-ALDRICH
Technique(s)cell culture - mammalian: suitable
Storage Temp.−20°C
Formpowder
Assay≥95% based on Mol. Wt. 12,173 basis

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