MOUSE PAI-1 ELISA KIT

Stock Code: 3588301
Manufacturer Part No: RAB1127-1KT

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Descriptions

Application

For research use only. Not for use in diagnostic procedures.Please refer to the attached Protocolfor details.

Biochem/physiol Actions

PAI-1 (plasminogen activator inhibitor) produced by platelets takes part in stabilizing blood clotting mechanism. PAI-1 prevents plasminogen activation during fibrinolysis. This might lead to the risk of cardiovascular disease. Elevated levels of PAI-1 has been observed in type 2 diabetes mellitus and serves the reason for reduced insulin sensitivity. PAI-1 stimulates the process of cellular senescence. PAI-1 regulation occurs through p53 dependent TGF-? (transforming growth factor-?) signalling. Studies also also predict that stress and depression might influence PAI-1 expression.

General description

This ELISA antibody pair detects mouse and human PAI-1.

The PAI-1 (plasminogen activator inhibitor) gene is localized to human chromosome 7q22.1. Active form of PAI-1 is expressed in the blood and tissues. Platelets harbor both the active and latent forms of PAI-1.

Other Notes

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.