Phosphotyrosine CSF1R / Macrophage Colony-stimulating Factor 1 Receptor ELISA Kit

Phosphotyrosine CSF1R / Macrophage Colony-stimulating Factor 1 Receptor ELISA Kit

Stock Code: 3588152
Manufacturer Part No: RAB0978-1KT
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Application


For research use only. Not for use in diagnostic procedures.Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)


Biochem/physiol Actions


CSF1R (colony stimulating factor 1 receptor) and its ligand CSF1 are linked to poor prognosis in patients with solid tumors and in patients with female reproductive cancers. In breast cancers with decreased claudin levels, this protein regulates the switch between proliferative and invasive state of the tumor, acting downstream of TGF? (tumor growth factor ?). Haploinsufficiency in this receptor might lead to aberration of microglial function, which might be a contributor to the pathogenesis of hereditary diffuse leukoencephalopathy with spheroids (HDLS).


General description


The antibody pair provided in this kit recognizes Human Tyrosine-Phosphorylated-MCSFR.


CSF1R (colony stimulating factor 1 receptor) or FMS, acts as a receptor for CSF1 and regulates monocyte and macrophage functioning. It is a member of the platelet-derived growth factor (PDGF) family of proteins and is a type III RTK (receptor tyrosine kinase). CSF1R is composed of five immunoglobulin (Ig)-like domains, a transmembrane region, a juxtamembrane domain and kinase insert domain (KID) intersecting the kinase domain.

ManufacturerSIGMA-ALDRICH
Technique(s)ELISA: suitable
Storage Temp.−20°C

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