SILu(TM) Prot ALB Albumin human

SILu(TM) Prot ALB Albumin human

Stock Code: 3587211
Manufacturer Part No: MSST0011-10UG
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Biochem/physiol Actions


Albumin is synthesized exclusively by the liver parenchymal cells at a rate of 14 g/day. While it is the most abundant plasma protein (>50%), increased urine albumin concentrations indicate bleedings in the lower urinary tract (ureter, bladder) or infections of the renal pelvis. A small abnormal albumin excretion is known as Microalbuminuria and serves as an indicator for temporary overload of the glomerular filtration (fever, excessive sports) or chronic injury of the glomeruli (diabetes).


General description


SILu™Prot ALB is a recombinant, stable isotope-labeled human albumin which incorporates [13C6, 15N4]-Arginine and [13C6, 15N2]-Lysine. Expressed in human 293 cells, it is designed to be used as an internal standard for bioanalysis of albumin in mass-spectrometry. SILu™Prot ALB is a monomer of 607 amino acids (including C-terminal polyhistidine and flag tags), with a molecular weight of ~69 kDa.


Legal Information


SILu is a trademark of Sigma-Aldrich Co. LLC


Physical form


Supplied as a lyophilized powder containing phosphate buffered saline.


Sequence


RRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGLDYKDDDDKGHHHHHHHHGGQ

Quality Level200
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
Formlyophilized powder
Assay≥98% (SDS-PAGE)

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