ENBRBRIDGE ELISA KIT

ENBRBRIDGE ELISA KIT

Stock Code: 3586602
Manufacturer Part No: ABK0011-1KT
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General description


A Protein Conformational Array (PCA) in a sandwich ELISA format where the plate is coated with a panel of antibodies raised against peptides derived from the full length protein sequence of Etanercept. Taken individually, each of these antibodies is strongly antigenic to the peptide sequence that was used in its production. However, when these peptides are incorporated into a full length correctly folded protein, the antigenicity of many of them is masked by the three dimensional structure of the protein and only a limited number of the antibodies respond. The result is a histogram which can be likened to a ‘;fingerprint’; for correctly folded Etanercept. For an Enbrel Biosimilar, if the protein is correctly folded and glycosylated, the ‘;fingerprint’; will match that of Etanercept. If it is not correctly folded, previously masked peptide sequences will be exposed and will be recognized by the antibody made to that exposed sequence. In this way, changes in the ‘;fingerprint’; generated by the ELISA will point out differences between the Biosimilar and authentic Etanercept.

ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C

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