Colcemid

Colcemid

Stock Code: 2795422
Manufacturer Part No: 10295892001
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Application


Colcemid inhibits the formation of mitotic spindles. It is used to increase the percentage of metaphase cells for chromosome analysis.


Biochem/physiol Actions


Often in karyotyping and cell cycle research it is desirable to increase the yield of mitotic cells in a particular phase of the cell cycle. This can be achieved in a variety of ways with the most popular being the use of a cell cycle synchronizing agent such as demecolcine. Demecolcine will arrest cells in metaphase with no remarkable effect on the biochemical events in mitotic cells or in synchronized G1 and S phase cells. White blood cells are often treated with demecolcine to arrest cells in metaphase.


General description


Colcemid is also known as demecolcine. Its generic name is N-methyl-N-deacetyl-colchicine. Colcemid depolymerizes microtubules and blocks mitosis at metaphase.


Other Notes


For life science research only. Not for use in diagnostic procedures.


Physical form


Solution (10 µg/ml), filtered through 0.2 µm pore size membrane.

Quality Level100
InChI keyNNJPGOLRFBJNIW-HNNXBMFYSA-N
InChI1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3/t15-/m0/s1
Further InfoN-methyl-N-deacetyl-colchicine
Impuritiesmicrobial, tested
Formsolution

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