Lysostaphin from Staphylococcus staphylolyticus, aseptically filled

Lysostaphin from Staphylococcus staphylolyticus, aseptically filled

Stock Code: 3579789
Manufacturer Part No: L2898-1MG
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Biochem/physiol Actions


Lysostaphin is a zinc endopeptidase with a molecular weight of approximately 25 kDa. Because lysostaphin cleaves the polyglycine cross-links in the peptidoglycan layer of the cell wall of Staphylococcus species it has been found useful for cell lysis and also as a potential anti-microbial therapeutic. pH Optimum for activity: ~7.5


Lysostaphin exhibit a lytic action againstStaphylococcus aureus. It possesses several functions of three major enzymes, such as, glycylglycine endopeptidase, endo-?-N-acetyl glucosamidase andN-acteyl muramyl-L-alanine amidase.Lysostaphin can be used to treat antibiotic-resistant staphylococcal infections. Lysostaphin being an antistaphylococcal agent, can be used as a preservative in the food industry and in clinical labs for rapid screening.


General description


Chemical structure: peptide


Lysostaphin is mainly liberated as a proenzyme. It is highly stable at pH 4 and temperature 5°C.


Preparation Note


Prepared from L 7386


Unit Definition


One unit will reduce the turbidity (A620) of a suspension of Staphylococcus aureus cells from 0.250 to 0.125 in 10 min at pH 7.5 at 37 °C in a 6.0 ml reaction mixture.

Quality Level200
ManufacturerSIGMA-ALDRICH
CompositionProtein, 40-70% biuret
Formpowder

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