Prostaglandin F Synthase human, recombinant, expressed in E. coli, >=90% (SDS-PAGE)

Prostaglandin F Synthase human, recombinant, expressed in E. coli, >=90% (SDS-PAGE)

Stock Code: 3579453
Manufacturer Part No: F7807-50UG
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Application


Prostaglandin F synthase (PGF synthase) is a member of the aldo-keto reductase superfamily of proteins which catalyze the conversion of aldehydes and ketones to thier corresponding alcohols. Prostaglandin F synthase is used in cancer research since it is upregulated in many cancers such as breast and prostate cancer. PGF synthase is also used to study kidney and renal cell carcinoma .


Biochem/physiol Actions


PGF synthase catalyzes the conversions of 4-androstene-3,17-dione to testosterone, estrone to 17?-estradiol, prostaglandin H2 to PGF2?, and PGD2 to 9?,11?-PGF2. Prostaglandin (PG) F2 is synthesized via three pathways .


Unit Definition


One unit is defined as the amount of enzyme required to produce 1 µmol of NADP per minute at 37°C in 50 mM KPO4 pH 7.2 containing 250 µM NADPH and 25 µM 9,10-phenanthrenequinone

Quality Level200
ManufacturerSIGMA-ALDRICH
Further Infocontains a C-terminal hexahistidine tag
Formliquid
Assay≥90% (SDS-PAGE)

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