Carboxylesterase 2 human, recombinant, expressed in mouse NSO cells, >=95% (SDS-PAGE)

Carboxylesterase 2 human, recombinant, expressed in mouse NSO cells, >=95% (SDS-PAGE)

Stock Code: 3579207
Manufacturer Part No: C4749-10UG
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£832.93 (exc VAT) per 10UG
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Biochem/physiol Actions


Human carboxylesterase 2 (hCE-2) recognizes a substrate with a large alcohol group and small acyl group. Its substrate specificity may be restricted by a capability of acyl-hCE-2 conjugate formation due to the presence of conformational interference in the active site pocket. Carboxylesterases catalyze the biotransformation of several ester-containing drugs and prodrugs such as angiotensin-converting enzyme inhibitor (temocarpil, cilazapril), anti-tumor drugs (capecitabin) and narcotics.


Member of a serine esterase family that hydrolyze ester and amide bonds. Carboxylesterase 2 is an endoplasmic reticulum-bound hydrolase that plays a critical role in xenobiotic detoxification and activation for ester-containing therapeutics. Carboxylesterase 2 is also involved in the detoxification of drugs such as heroin and cocaine. This enzyme is thought to play a role in lipid metabolism.


Physical form


Supplied as a solution containing sodium chloride, sodium acetate, and 20% glycerol.


Unit Definition


One unit will cause the hydrolysis of 1 picomole of p-nitrophenylacetate per minute at pH 7.5 at 25 deg C.

Quality Level200
ManufacturerSIGMA-ALDRICH
Impurities≤1.0 EU/µg endotoxin
Formsolution
Assay≥95% (SDS-PAGE)

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